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현재경 교수

HYUN JAEKYUNG

INFO

  • 소속캠퍼스한국기초과학지원연구원
  • 전공 생물분석과학
  • 연락처043-240-5442
  • 출신전공Structural biology
  • 학위박사
  • 최종출신대학University of Auckland
  • 이메일

연구분야

초저온 전자현미경법 활용 단백질 복합체 구조분석

Structural analysis of protein complexes using cryo-electron microscopy

대표연구실적

-  Jeong et al. / Pseudoatomic structure of the tripartite multidrug efflux pump AcrAB-TolC reveals the intermeshing cogwheel-ile interaction between AcrA and TolC/ Structure/ 2016-02-02 -  Hyun et al. / Membrane remodeling by the double-barrel scaffolding protein of Poxvirus / PLoS Pathogens / 2011-09-08 -  Gwak et al. / An intracellular antifreeze protein from Antarctic microalga that responds to various environmental stresses / FASEB Journal / 2014-08-11

논문(최근 5년)

-  Novel glyoxalases from Arabidopsis thaliana[FEBS Journal,2013-06-05] -  Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents[Bioorganic and Medicinal Chemistry Letters,2013-06-14] -  Discovery of novel histidine-derived lipo-amino acids: Applied in the synthesis of ultra-short antimicrobial activity salt resistance and protease stability[European Journal of Medicinal Chemistry,2013-07-26] -  Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate[Antiviral Research,2013-08-15] -  De novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities[PLoS One,2013-11-26] -  Bacteria killing mechanism of sheep myeloid antimicrobial peptide-18(SMAP-18) and its Trp-substituted analog with improved cell selectivity and reduced mammalian cell toxicity[Amino Acids,2014-06-13] -  Expression purification and characterization of human vacuolar-type H+-ATPase subunit d1 and d2 in Escherichia coli[Protein Expression and Purification,2014-03-12] -  Enhancement of antibacterial activity of short tryptophan-rich antimicrobial peptide Pac-525 by replacing Trp with His(chx)[Bulletin of the Korean Chemistry Society,2014-05-30] -  Poly-Lysine Peptidomimetics Having Potent Antimicrobial Activity without Hemolytic Activity[Aminno Acids,2014-06-25] -  An intracellular antifreeze protein from an Antarctic microalga that responds to various environmental stresses[FASEB Journa,2014-08-11] -  Construction of target-specific virus-like particles for the delivery of algicidal compounds to harmful algae[ ENVIRONMENTAL MICROBIOLOGY,2015-04-01] -  Structure of the tripartite multidrug efflux pump AcrAB-TolC suggests an alternative assembly mode[ MOLECULES AND CELLS,2015-02-28] -  Regulation Mechanism of the ald Gene Encoding Alanine Dehydrogenase in Mycobacterium smegmatis and Mycobacterium tuberculosis by the Lrp/AsnC Family Regulator AldR[ JOURNAL OF BACTERIOLOGY,2015-01-20] -  Pseudoatomic structure of the tripartite multidrug efflux pump AcrAB-TolC reveals the intermeshing cogwheel-like interaction between AcrA and TolC[ STRUCTURE,2016-02-02] -  Pyrazole derived ultra-short antimicrobial pepridomimetics with potenet anti-biofilm activity[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-09-23] -  In vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes under physiological conditions[ SCIENTIFIC REPORTS,2017-06-06]

연구과제 수행 실적

다중 tRNA 합성효소 복합체의 고분해능 구조 분석 대용량 Bio-EM 데이터를 활용한 3차원 단백질 구조분석 플랫폼 구축 멀티스케일 융합현미경의 시료스테이지 및 나노블레이드 장치개발 엑소좀 바이오 마커의 실시간 관찰을 위한 그래핀 아쿠아리움 전자현미경