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장익순 교수

Jang Ik Soon

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  • 소속캠퍼스한국기초과학지원연구원
  • 전공 생물분석과학
  • 연락처042-865-3430
  • 출신전공생화학
  • 학위박사
  • 최종출신대학서울대학교
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연구분야

노화 및 노화관련 질환의 분자기전 연구

Molecular mechanism for Aging and Age-related diseases

대표연구실적

-  Yang KE, Jang HJ, Hwang IH, Chung YH, Choi JS, Lee TH, Chung YJ, Lee MS, Lee MY, Yeo EJ, Jang IS/Phenyl 2-pyridyl ketoxime induces cellular senescence-like alterations via nitric oxide production in human diploid fibroblasts./Aging Cell./2016 Apr;15(2):245-55 -  Hwang IH, Park J, Kim JM, Kim SI, Choi JS, Lee KB, Yun SH, Lee MG, Park SJ, Jang IS/Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells./FASEB J./2016 May 31. pii: fj.201600240RR -  Lee DG, Jang IS, Yang KE, Yoon SJ, Baek S, Lee JY, Suzuki T, Chung KY, Woo SH, Choi JS/Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes./Acta Pharm./ 2016 Jun 1;66(2):297-302

논문(최근 5년)

-  Effect of rutin from tatary buckwheat sprout on serum glucose-lowering in animal model of type2 diabetes [ACTA PHARMACEUTICA,2016-04-08] -  Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/beta-catenin signaling pathway in human pancreatic beta cell[ FASEB JOURNAL,2016-05-31] -  Phenyl 2-pyridyl ketoxime induces cellular senescence-like alterations via nitric oxide production in human diploid fibroblasts[AGING CELL,2015-11-08] -  Direct regulation of TLR5 expression by caveolin-1[ MOLECULES AND CELLS,2015-10-25] -  Flagellin-dependent TLR5/caveolin-1 as a promising immune actibvator in immunosenescence[AGING CELL,2015-06-30] -  The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flus via interaction with the vacuolar ATPase[AUTOPHAGY,2015-03-19] -  Spatially-resolvbed exploration of the mouse brain glycome by tissue glyco-capture(TGC) and nano-LC/MS[ ANALYTICAL CHEMISTRY,2015-02-02] -  Caveolin-1-dependent and -independent uPAR signaling pathways contribute to ganglioside GT1b induced early apoptosis in A549 lung cancer cells[AMERICAN JOURNAL OF CANCER RESEARCH,2014-11-30] -  An enzymatically fortitied ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and IkBa[MOLECULAR MEDICINE REPORTS,2014-06-17] -  Anti-proliferative effects of ginsenosides extracted from mountain ginseng on lung cancer[CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2016-05-18] -  INHIBITION OF cyp4a REDUCES HEPATIC ENDOPLASMIC RETICULUM STRESS AND FEATURES OF DIABETES IN MICE[ GASTROENTEROLOGY,2014-10-15] -  Simulated microgravity contributes to autophagy insuction by regulating AMP-activated protein kinase[DNA AND CELL BIOLOGY,2014-03-27] -  Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3[JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2018-07-24] -  Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018-09-11] -  Quantitative Analyses of the Functional Constituents in SanYangSam and SanYangSanSam[Journal of Pharmacopuncture,2017-11-24] -  AMPK contributes to autophagosome maturation and lysosomal fusion[Scientific Reports,2018-08-23] -  Medium chain unsaturated fatty acid ethyl esters inhibit persister formation of Escherichia coli via antitoxin HipB.[Applied Microbiology and Biotechnology,2018-08-07] -  Antidepressant-Like Effects of Gyejibokryeong-hwan in a Mouse Model of Reserpine-Induced Depression[BioMed Research International,2018-06-26] -  Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling[Cell Death and Disease,2018-06-28] -  Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated Akt/NF-κB signaling pathway[Cell Death and Disease,2018-05-23] -  Restoring Effects of Natural Anti-Oxidant Quercetin on Cellular Senescent Human Dermal Fibroblasts[AMERICAN JOURNAL OF CHINESE MEDICINE,2018-05-08] -  BTNET : boosted tree based gene regulatory network inference algorithm using time-course measurement data[BMC SYSTEMS BIOLOGY,2018-03-19] -  TSC-22 inhibits CSF-1R function and induces apoptosis in cervical cancer[Oncotarget,2017-08-16] -  Monitoring of post-mortem changes of saliva N-glycosylation by nano LC/MS[Analytical and Bioanalytical Chemistry,2017-11-21] -  Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression.[PLOS ONE,2017-10-18] -  Anti-cancer effect of Scutellaria baicalensis in combination with cisplatin in human ovarian cancer cell[BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2017-05-25] -  Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells[CURRENT ONCOLOGY REPORTS,2016-10-17] -  Diagnostic and prognostic relevance of CP2c and YY1 expression in hepatocellular carcinoma[Oncotarget,2017-02-17] -  Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway[AMERICAN JOURNAL OF CANCER RESEARCH,2017-03-15] -  Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway[Scientific Reports,2017-03-21] -  Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma.[Oncotarget,2017-01-14] -  Allergen-Removed Rhus verniciflua Extract Induces Ovarian Cancer Cell Death via JNK Activation.[American Journal of Chinese Medicine,2016-11-16] -  Growth inhibitory and apoptosis-inducing effects of allergen-free Rhus verniciflua Stokes extract on A549 human lung cancer cells[CURRENT ONCOLOGY REPORTS,2016-05-20] -  Houttuynia cordata Thunb Promotes Activation of HIF-1A-FOXO3 and MEF2A Pathways to Induce Apoptosis in Human HepG2 Hepatocellular Carcinoma Cells[INTEGRATIVE CANCER THERAPIES,2016-08-27]

특허(최근 5년)

-  육두구 추출물 또는 이로부터 분리된 리그난계 화합물을 함유하는 시르투인 활성화에 의해 매개되는 질환의 예방 또는 치료용 조성물[2014-04-29] -  노화 및 노화 관련 질환의 예방, 개선 또는 치료용 조성물[2018-02-02] -  테트라스파닌-2를 이용한 당뇨병의 예방 또는 치료용 조성물과 당뇨병 치료제 스크리닝 방법[2018-06-19]

연구과제 수행 실적

NBIT 융합기술 기반 생체 인산화 신호 체계 제어 연구(인산화효소 단백질 상호작용 분석) NLCA를 이용한 한약의 작용기전 규명 및 작용점 연구 육두구를 이용한 항노화 및 항산화 건강기능식품 개발 육두구에서 분리한 Nectandrin B(리그난계화합물)을 활용한 항노화 화장료 및 화장품 개발 췌장암세포의 전이시간별 발현된 전사인자 활성 및 네트워크 연구 아코닌을 이용한 항통증 연구 아코닌을 이용한 항통증 연구 육두구 추출믕(리그난계화합물)을 이용한 항노화 화장료 및 화장품 개발 육두구 추출물을 활용한 항노화 개별기능인증소재 개발 췌장암세포의 전이시간발현별 전사인자 네트워크 분석