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장익순 교수

Jang Ik Soon

INFO

  • 소속캠퍼스한국기초과학지원연구원
  • 전공 생물분석과학
  • 연락처042-865-3430
  • 출신전공생화학
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일

연구분야

노화 및 노화관련 질환의 분자기전 연구

Molecular mechanism for Aging and Age-related diseases

대표연구실적

-  Yang KE, Jang HJ, Hwang IH, Chung YH, Choi JS, Lee TH, Chung YJ, Lee MS, Lee MY, Yeo EJ, Jang IS/Phenyl 2-pyridyl ketoxime induces cellular senescence-like alterations via nitric oxide production in human diploid fibroblasts./Aging Cell./2016 Apr;15(2):245-55 -  Hwang IH, Park J, Kim JM, Kim SI, Choi JS, Lee KB, Yun SH, Lee MG, Park SJ, Jang IS/Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells./FASEB J./2016 May 31. pii: fj.201600240RR -  Lee DG, Jang IS, Yang KE, Yoon SJ, Baek S, Lee JY, Suzuki T, Chung KY, Woo SH, Choi JS/Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes./Acta Pharm./ 2016 Jun 1;66(2):297-302

논문(최근 5년)

-  Effect of rutin from tatary buckwheat sprout on serum glucose-lowering in animal model of type2 diabetes [ACTA PHARMACEUTICA,2016-06-01] -  Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/beta-catenin signaling pathway in human pancreatic beta cell[ FASEB JOURNAL,2016-05-31] -  Phenyl 2-pyridyl ketoxime induces cellular senescence-like alterations via nitric oxide production in human diploid fibroblasts[AGING CELL,2016-04-22] -  Direct regulation of TLR5 expression by caveolin-1[ MOLECULES AND CELLS,2015-12-12] -  Flagellin-dependent TLR5/caveolin-1 as a promising immune actibvator in immunosenescence[AGING CELL,2015-10-25] -  The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flus via interaction with the vacuolar ATPase[AUTOPHAGY,2015-04-15] -  Spatially-resolvbed exploration of the mouse brain glycome by tissue glyco-capture(TGC) and nano-LC/MS[ ANALYTICAL CHEMISTRY,2015-03-05] -  Caveolin-1-dependent and -independent uPAR signaling pathways contribute to ganglioside GT1b induced early apoptosis in A549 lung cancer cells[AMERICAN JOURNAL OF CANCER RESEARCH,2014-11-18] -  An enzymatically fortitied ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and IkBa[MOLECULAR MEDICINE REPORTS,2015-01-20] -  Anti-proliferative effects of ginsenosides extracted from mountain ginseng on lung cancer[CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2016-05-18] -  INHIBITION OF cyp4a REDUCES HEPATIC ENDOPLASMIC RETICULUM STRESS AND FEATURES OF DIABETES IN MICE[ GASTROENTEROLOGY,2014-10-15] -  Simulated microgravity contributes to autophagy insuction by regulating AMP-activated protein kinase[DNA AND CELL BIOLOGY,2014-03-27] -  Ginsenoside Rg3 up-regulates the expression of vascular endothelial growth factor in human dermal papilla cells and mouse hair folicles[PHYTOTHERAPY RESEARCH,2014-07-23]

특허(최근 5년)

-  육두구 추출물 또는 이로부터 분리된 리그난계 화합물을 함유하는 시르투인 활성화에 의해 매개되는 질환의 예방 또는 치료용 조성물[2014-04-29] -  소고기 월령판별용 SPR 키트 ㅣ및 이를 이용한 소고기 월령판별 방법[2014-02-13]

연구과제 수행 실적

NBIT 융합기술 기반 생체 인산화 신호 체계 제어 연구(인산화효소 단백질 상호작용 분석) NLCA를 이용한 한약의 작용기전 규명 및 작용점 연구 육두구를 이용한 항노화 및 항산화 건강기능식품 개발 육두구에서 분리한 Nectandrin B(리그난계화합물)을 활용한 항노화 화장료 및 화장품 개발 췌장암세포의 전이시간별 발현된 전사인자 활성 및 네트워크 연구