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이창준 교수

Changjoon Justin Lee

INFO

  • 소속캠퍼스기초과학연구원
  • 전공 기초과학
  • 연락처02-958-6940
  • 출신전공Physiology and Cellular Biophysics
  • 학위박사
  • 최종출신대학Columbia University
  • 이메일

연구분야

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Glia-neuron interaction, Receptor and ion channel function, Neurodegenerative diseases, Brain cancer.

대표연구실적

-  Seonmi Jo, Oleg Yarishkin, Yu Jin Hwang,Ye Eun Chun, Mijeong Park,Dong Ho Woo,Jin Young Bae, Taekeun Kim, Jaekwang Lee, Heejung Chun, Hyun Jung Park, Da Yong Lee, Jinpyo Hong, Hye Yun Kim, Soo-Jin Oh, Seung Ju Park, Hyo Lee, Bo-Eun Yoon, YoungSoo Kim, Yong Jeong, Insop Shim, Yong Chul Bae, Jeiwon Cho, Neil W Kowall, Hoon Ryu, Eunmi Hwang, Daesoo Kim, C Justin Lee/GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease/Nature Medicine/29 June 2014 -  TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation/Cell/28 September 2012 -  Soojung Lee, Bo-Eun Yoon, Ken Berglund, Soo-Jin Oh, Hyungju Park, Hee-Sup Shin, George J. Augustine, C. Justin Lee/Channel-Mediated Tonic GABA Release from Glia/Science/3 September 2010

논문(최근 5년)

-  GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease[Nature medicine,2014-08-01] -  Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice[Proceedings of the National Academy of Sciences of the United States of America,2014-08-01] -  Glial GABA synthesized by monoamine oxidase B mediates tonic inhibition[The Journal of Physiology,2014-09-19] -  A multichannel neural probe with embedded microfluidic channels for simultaneous in vivo neural recording and drug delivery[Lab on a chip,2015-02-01] -  Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition[The Journal of physiology,2014-11-01] -  Nanomechanical measurement of astrocyte stiffness correlated with cytoskeletal maturation[Journal of biomedical materials research. Part A,2015-01-01] -  TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus[Molecular Brain,2014-11-01] -  Three-dimensional brain-on-a-chip with an interstitial level of flow and its application as an in vitro model of Alzheimer's disease[Lab on a chip,2015-01-01] -  Neural probes with multi-drug delivery capability[Lab on a chip,2015-08-01] -  A multichannel neural probe with embedded microfluidic channels for simultaneous in vivo neural recording and drug delivery[Lab on a chip,2015-03-01] -  Suppression of 14-3-3γ-mediated surface expression of ANO1 inhibits cancer progression of glioblastoma cells[Scientific Reports,2016-05-01] -  EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-b oligomers and plaques[Nature Communications,2015-12-01] -  Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system[Biomaterials,2015-12-01] -  TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF[Brain : a journal of neurology,2015-12-01] -  Ultra-sensitive detection of brain-derived neurotrophic factor (BDNF) in the brain of freely moving mice using an interdigitated microelectrode (IME) biosensor[Scientific Reports,2016-09-01] -  The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons.[NATURE COMMUNICATIONS,2016-12-19] -  Trifluoperazine, a Well-Known Antipsychotic, Inhibits Glioblastoma Invasion by Binding to Calmodulin and Disinhibiting Calcium Release Channel IP3R.[ MOLECULAR CANCER RESEARCH,2017-01-16] -  Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network.[NATURE COMMUNICATIONS,2017-02-01] -  Bestrophin 1 and retinal disease.[ PROGRESS IN RETINAL AND EYE RESEARCH,2017-01-30] -  Direct interaction with 14-3-3 gamma promotes surface expression of Best1 channel in astrocyte[Molecular Brain,2017-11-01]

특허(최근 5년)

-  퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물 및 이의 스크리닝 방법[2014-09-01] -  성상교세포의 글루타메이트 방출 기작[2014-07-03] -  성상교세포의 글루타메이트 방출 기작[2014-10-28] -  클로라이드 채널 차단제로 유용한 화합물[2014-11-17] -  페녹시프로판올 유도체 및 이를 함유하는 약학적 조성물[2014-12-18] -  소뇌에서의 GABA 방출 조절제[2015-08-04] -  망막의 ONOFF 이극세포 선택적 유전자 발현 방법[2016-02-05] -  소뇌에서의 GABA 방출 조절제[2016-03-25] -  항암활성을 가지는 페노싸이아진 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 약학적 조성물[2016-08-03] -  클로라이드 채널 차단제로 유용한 화합물[2017-12-05] -  Aquaporin 4 (AQP4) 유전자의 단일염기다형성 분석을 통한 인지기능 예측[2017-12-06]