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이선경 교수

Lee, Sunkyung

INFO

  • 소속캠퍼스한국화학연구원 스쿨
  • 전공 의약화학 및 약리생물학
    (의약화학)
  • 연락처042-860-7148
  • 출신전공의약화학
  • 학위박사
  • 최종출신대학Purdue University
  • 이메일

연구분야

의약화학

medicinal chemistry

대표연구실적

-  (5-Arylfuran-2-ylcarbonyl)guanidines as Cardioprotectives through the Inhibition of Na+/H+ Exchanger Isoform-1, J. of medicinal chemistry, p 2881, 2005 -  A Novel and Orally Active Poly(ADP-Ribose) Polymerase Inhibitor, KR-33889)[2-[Methoxycarbony(4-methoxyphenyl)methylsulfanyl]-1H-benzimidazole-4-carboxylic Acid Amide], J. OF PHARMACOLOGY AND EXP. THERAPEUTICS pg 10, 2009 -  (2-Aryl-5-methylimidazol-4-ylcarbonyl)guanidines and (2-Aryl-5-methyloxazol-4-ylcarbonyl)guanidines as NHE-1 inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009

논문(최근 5년)

-  Discovery of 4-(Phenyl)thio-1H-pyrazole Derivativees as Agonists of GPR109A, a High Affinity Niacin Receptor[Archives of Pharmacal Research,2015-01-20] -  Octahydrocyclopenta[c]pyridine and Octahydrocyclopenta[c]pyran Analogues as a Platelet Activated Receptor-1 (PAR1) Antagonist[Archives of Pharmacal Research,2015-11-01] -  protease activated receptor 1 natagonist ameliorates the clinical symproms of experimental autoimmune encephalomyelitis via inhibiting breakdown of blood-brain barrier[ JOURNAL OF NEUROCHEMISTRY,2015-10-11] -  Trans-fused 5-[(tert-Butoxtycarbonyl)amino]octahydroindenes as a Protease Activated Receptor-1 (PAR1) Antagonist[Archives of Pharmacal Research,2016-10-18]

특허(최근 5년)

-  아자티오프린을 유효성분으로 함유하는 뇌종양 또는 테모달내성교모세포종예방또는치료용약학적조성물[2016-12-07]

연구과제 수행 실적

AIMP2-DX2를 타겟으로하는 항암물질 발굴연구