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정관령 교수

Kwan-Young Jung

INFO

  • 소속캠퍼스한국화학연구원 스쿨
  • 전공 의약화학 및 약리생물학
    (의약화학)
  • 연락처042-860-7692
  • 출신전공의약화학
  • 학위박사
  • 최종출신대학광주과학기술원
  • 이메일

연구분야

Medicinal chemistry, Organic Chemistry, Chemical Biology

의약화학, 유기화학, 화학생물학

대표연구실적

-  Kwan-Young Jung et al./ Amphipathic alpha-helix mimetics based on a 1,2-diphenylacetylene scaffold/ Organic Letters/ 2013, 15, 3234-3237 -  Kwan-Young Jung et al./ Perturbation of the c-Myc-Max protein-protein interaction via synthetic α?helix mimetics/ Jorunal of Medicinal Chemistry/ 2015, 58, 3002-3024 -  Kwan-Young Jung et al./ Fine-tuning the chemo- and regioselective alkylation of 1,4-benzodiazepines: further applications of the Mitsunobu reaction/ MedChemComm/ 2012, 3, 1160-1163

논문(최근 5년)

-  Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014-07-28] -  Perturbation of the c-Myc-Max Protein-Protein Interaction via Synthetic α-Helix Mimetics[Journal of Medicinal Chemistry,2015-03-03] -  Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf[ BIOCHEMICAL JOURNAL,2015-05-01] -  Design, synthesis, and biological evaluation of aryl N-methoxyamide[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-08-15] -  Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor[ BIOCHEMICAL PHARMACOLOGY,2017-11-15] -  Deacetylation of unactivated amide bonds in heterocyclic systems using t-BuOK[ CHEMISTRYSELECT,2018-02-01] -  Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-12-01] -  Synthesis and biological evaluation of indazole-4,7-dione derivatives as novel BRD4 inhibitor[ ARCHIVES OF PHARMACAL RESEARCH,2018-01-01]

연구과제 수행 실적

PPI 저해전략을 이용한 Clathrin-AP2 단백질 저해제 개발