본문 바로가기 대메뉴 바로가기
Myung Ae Bae(Professor)

INFO

  • AffiliationKRICT School
  • Majors Medicinal Chemistry and Pharmacology
    (Pharmacology)
  • Contact Information042 860 7084
  • Major미생물학
  • DegreePh.D.
  • Highest Level of Education경북대학교
  • E-Mail

Field of Research

New Drug Discovery

Research Results

-  Bae MA외 9인/A novel assessment of nefazodone-induced hERG inhibition by electrophysiological and stereochemical method/Toxicology and Applied Pharmacology/Feb.2014 -  Bae MA외 6인/Predicted drug-induced bradycardia related cardio toxicity using a zebrafish in vivo model is highly correlated with results from in vitro tests/Toxicology Letters/January 2013 -  배명애/INDENONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME/1149529/2012-05-17

Treatise

-  KR-62980 Suppresses Lipid Metabolism Through Inhibition of Cytosolic NADP Isocitrate Dehydrogenase in Zebrafish[Zebrafish,2014-04-01] -  Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay[J.Med.chem,2014-09-01] -  Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists[Bioorg Med Chem Lett,2014-09-01] -  Novel TAZ modulators enhance myogenic differentiation and muscle regeneration.[Br J Pharmacol,2014-09-01] -  Determination of a novel diacylglycerol acyltransferase 1 inhibitor 2-[4-(4-{5-[2-phenyl-5-(trifluoromethyl) oxazole-4-carboxamido]-1H-benzo[d]imidazol-2-yl} phenyl) cyclohexyl] acetic acid (KR-6923[Biomed Chromatogr.,2014-03-01] -  Determination of a novel phosphodiesterase4 inhibitor 3-[1-(3cyclopropylmethoxy-4-difluoromethoxybenzyl)-1H-pyrazol-3-yl]-benzoic acid (PDE-423) in rat plasma using liquid chromatography-tandem mass[Biomed Chromatogr,2014-07-01] -  Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid a novel DGAT-1 inhibitor[Xenobiotica,2014-05-01] -  Transport characteristics and transporter-based drug-drug interactions of TM-25659 a novel TAZ modulator[Biopharm Drug Dispos,2014-04-01] -  Determination of 2-(3-Benzoyl)-4-Hydroxy-11-Dioxo-2H-12-Benzothiazine-2-yl-1-Phenylethanone by Liquid Chromatography-Tandem Mass Spectrometry.[J Chromatogr Sci.,2014-06-01] -  Synthesis and Diacylglycerol Acyltransferase-1 Inhibition of Azabicyclo[3.1.0]hexane Derivatives[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2015-07-05] -  Synthesis and biological evaluation of α-sulfonamido-[ MEDCHEMCOMM,2015-05-25] -  Discovery and optimization of adamantane carboxylic acid derivatives[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2015-07-27] -  P-Glycoprotein, not BCRP, Limits the Brain Uptake of [(18)F]Mefway in Rodent Brain.[ MOLECULAR IMAGING AND BIOLOGY,2015-08-07] -  TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways.[ MOLECULES AND CELLS,2016-08-23] -  Pharmacokinetic characterization of 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone, a novel 11β-hydroxysteroid dehydrogenase type 1 inhibitor in rats.[ ARCHIVES OF PHARMACAL RESEARCH,2016-01-18] -  Expression of miRNA-122 Induced by Liver Toxicants in Zebrafish.[ BIOMED RESEARCH INTERNATIONAL,2016-06-04] -  PPARγ agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARγ phosphatase.[ INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2016-10-22] -  Treatment of Sepsis Pathogenesis with High Mobility Group Box Protein 1-Regulating Anti-inflammatory Agents.[ JOURNAL OF MEDICINAL CHEMISTRY,2017-01-20] -  Zebrafish as a Screening Model for Testing the Permeability of Blood-Brain Barrier to Small Molecules.[ ZEBRAFISH,2017-08-12] -  Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists.[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-07-13] -  Development and validation of a liquid chromatography-tandem mass spectrometry method for pharmacokinetic study of TM-53, a novel transcriptional coactivator with PDZ-binding motif (TAZ) modulator[ JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017-08-31] -  Anti-Adipogenic Effects on 3T3-L1 Cells and Zebrafish by Tanshinone IIA[ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017-09-27]

Patent

-  티에노피리미딘 유도체 이의 약학적으로 허용가능한 염 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨 관련 질환의 예방 또는 치료용 약학적 조성물[2014-05-23] -  페닐테트라졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 골다공증 또는 비만의 예방 또는 치료용 약학적 조성물[2014-05-09] -  사이클로프로필기를 갖는 아릴설폰아마이드 유도체, 이의 약학적으로 허용 가능한 염 및 이의[2014-11-19] -  신규한 베타 알라닌 유도체, 약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약제[2014-12-08] -  혈관 이미징용 형광 프로브 및 그의 용도[2015-09-17] -  아다만틸기를 갖는 헤테로고리 카복스아미드 유도체, 이의 제조방법 및 이를 유효성분으로 함[2017-10-24] -  콜포신 다로페이트를 포함하는 골 질환의 예방 또는 치료용 조성물[2016-09-06] -   3-(4-클로로페닐)벤조[4, 5]이미다조[2, 1-b]싸이아졸-6-카복실산을 포함하는 항비만 또는 항[2017-03-17]