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Ahn, Sunjoo(Professor)

INFO

  • AffiliationKRICT School
  • Majors Medicinal Chemistry and Pharmacology
    (Pharmacology)
  • Contact Information042-860-7170
  • MajorPharmaceutics
  • DegreePh.D.
  • Highest Level of EducationOhio State University
  • E-Mail

Field of Research

Pharmaceutics, Pharmacokinetics (ADME), Biopharmaceutics, Pharmacology and Toxicity

Research Results

-  S Ahn, JD. Kearbey, C Duke III, CM Barrett, CM Li, DD Miller, JT Dalton, Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo phamacokinetics in mice. Drug Metabolism and Disposition, 39(4):636-643, 2011 Apr 01 -  S Ahn, DJ Hwang, CM Barrett, J Yang, C Duke III, DD Miller, JT Dalton, A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer. Cancer Chemotherapy and Pharmacology, 67(2):293-304, 2011 Feb -  S Ahn, C Duke III, CM Barrett, DJ Hwang, CM Li, DD Miller, JT Dalton, I-387, a Novel Antimitotic Indole, Displays a Potent In vitro and In vivo Antitumor Activity with Less Neurotoxicity. Molecular Cancer Therapeutics, 9(11):2859-2868, 2010 Nov

Treatise

-  Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid a novel DGAT-1 inhibitor[Xenobiotica,2014-05-01] -  KR-62980 suppresses lipid metabolism through inhibition of cytosolic NADP isocitrate dehydrogenase in zebrafish[Zebrafish,2014-04-11] -  Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice[Oncotarget,2014-05-15] -  Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling[PLos One,2014-07-29] -  Design Synthesis and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents[Journal of Medicinal Chemistry,2014-08-14] -  Design, Synthesis, and Evaluation of 2,4-Di(piperidine-substituted-anilino)pyrimidine Derivatives as ALK Inhibitors[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2015-07-17] -  Synthesis and evaluation of novel 2,4-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-09-15] -  Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats[ARCHIVES OF PHARMACAL RESEARCH,2015-05-09] -  Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): synthesis, in vitro, ex vivo, and in vivo efficacy studies[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-04-01] -  Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer[ CANCER LETTERS,2016-03-04] -  Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors[ BIOORGANIC & MEDICINAL CHEMISTRY,2016-01-15] -  Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-01-27] -  Zebrafish as a Screening Model for Testing the Permeability of Blood-Brain Barrier to Small Molecules[ ZEBRAFISH,2017-08-01] -  Development and validation of a liquid chromatography-tandem mass spectrometry method for pharmacokinetic study of TM-53, a novel transcriptional coactivator with PDZ-binding motif (TAZ) modulator[ JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017-11-30] -  Pharmacokinetics of Tafamidis, a Transthyretin Amyloidosis Drug, in Rats[ XENOBIOTICA,2017-08-14] -  Synthesis and Molecular Modeling Studies of[ MOLECULES,2017-11-09]

Patent

-  COMPOUNDS FOR TREATMENT OF CANCER[2015-07-22] -  COMPOUNDS FOR TREATMENT OF CANCER[2016-05-10] -  COMPOUNDS FOR TREATMENT OF CANCER[2016-02-05] -  METHOD OF TREATING ANDROGEN RECEPTOR (AR) -POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS)[2017-03-28] -  METHOD OF TREATING ANDROGEN RECEPTOR (AR) -POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS)[2017-04-18] -  피리미딘-24-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물[2016-09-05] -  4-(2-아미노-테트라하이드로나프탈렌닐) 유도체 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물[2016-08-29] -  피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물[2017-04-28] -  METHOD OF TREATING ANDROGEN RECEPTOR (AR) -POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS)[2017-03-28] -  METHOD OF TREATING ANDROGEN RECEPTOR (AR) -POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS)[2017-03-28] -  Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) [2017-03-28] -  Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) [2017-04-17] -  Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)[2017-04-18] -  Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)[2017-04-18] -  Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)[2017-03-28] -  compounds for treatment of cancer[2014-09-02] -  compounds for treatment of cancer[2015-05-12] -  compounds for treatment of cancer[2016-09-02] -  compounds for treatment of cancer[2016-09-20] -  compounds for treatment of cancer[2015-12-09] -  Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)[2017-04-18] -  Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)[2017-03-28] -  4-(2-아미노-테트라하이드로나프탈렌닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물[2016-08-29]