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Jong Yeon Hwang(Professor)

INFO

  • AffiliationKRICT School
  • Majors Medicinal Chemistry and Pharmacology
    (Medicinal Chemistry)
  • Contact Information042-860-7045
  • Major유기화학
  • DegreePh.D.
  • Highest Level of Education서강대학교
  • E-Mail
Personal Homepage

Field of Research

Medicinal Chemistry, Anticancer drug disocvery, chemical biology

Research Results

-  [Korea Research Institute of Chemical Technology-항암제 개발을 위한 의약화학 및 화학생물학 (medicinal chemistry and chemical biology for anticancer drug discovery)] Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for anaplastic lymphoma kinase (ALK) inhibitor ;Bioorg Med Chem Lett. 2017 May 15;27(10):2185-2191 -  [Institut Pasteur Korea-C형 간염치료제 개발 (anti-HCV drug discovery)] Characterization and structure-activity relationship study of iminodipyridinopyrimidines as novel hepatitis C virus inhibitor.Eur J Med Chem. 2017 Nov 10;140:65-73. -  [St. Jude Children's Research Hospital-화학생물학 및 소외질병치료제 개발 (chemical biology and neglected disease)] Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors; J. Med. Chem., 2012, 55(5), 2301-2310.

Treatise

-  Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action[Euorpean Journal of Medicinal Chemistry,2014-03-13] -  Discovery of a novel 26-difunctionalized 2H-benzopyran inhibitors toward sphingosylphosphorylcholine synthetic pathway as new anti-inflammatory target[Bulletin of the Korean Chemical Society,2014-08-20] -  Discovery of substituted 6-phenyl-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitors[Bioorganic Medicinal Chemistry Letters,2014-11-01] -  Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[32-d]pyrimidine derivatives as novel HIV-1 replication inhibitors[Bioorganic Medicinal Chemistry Letters,2014-10-23] -  Design Synthesis and Evaluation of 24-Di(piperidine-substituted-anilino)pyrmidine Derivatives as ALK Inhibitors[Bulletin of the Korean Chemical Society,2015-06-28] -  Development of potent ALK inhibitor and its molecular inhibitory mechanism against NSCLC harboring EML4-ALK proteins[Biochemical and Biophysical Research Communications,2015-08-28] -  Synthesis and evaluation of novel 24-diaminopyrimidines bearing bicyclic aminobenzazepines for anaplastic lymphoma kinase (ALK) inhibitor[Bioorganic Medicinal Chemistry Letters,2015-09-15] -  Discovery of novel tetrahydroisoquinoline-containing pyrimidines as ALK inhibitors[ BIOORGANIC & MEDICINAL CHEMISTRY,2016-01-15] -  Minor modifications to ceritinib enhance anti-tumor activity in EML4-ALK positive cancer[ CANCER LETTERS,2016-05-01] -  Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): Synthesis, in vitro, ex vivo, and in vivo efficacy studies[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-04-01] -  Benzothiazepinecarboxamides: Novel hepatitis C virus inhibitors that interfere with viral entry and the generation of infectious virions[ ANTIVIRAL RESEARCH,2016-05-01] -  Discovery of substituted pyrazol-4-yl pyridazinone derivatives as novel c-Met kinase inhibitors[ARCHIVES OF PHARMACAL RESEARCH,2016-01-11] -  Design and Synthesis of Novel Pyrazolo[3,?4-?d]?pyrimidin-?1-?yl piperidine Derivatives as Bruton's Tyrosine Kinase Inhibitors[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2017-02-07] -  Replacing the terminal piperidine in ceritinib with aliphatic amines confers activities against crizotinib-resistant mutants including G1202R[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-01-27] -  Characterization and structure-activity relationship study of[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-09-06] -  Synthesis and biological evaluation of N9-cis-cyclobutylpurine[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-08-12] -  Novel 2,4-diaminopyrimidines bearing fused tricyclic ring moiety for[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-05-19] -  Synthesis and Molecular Modeling Studies of N′-Hydroxyindazolecarboximidamides as Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors[ MOLECULES,2017-11-09] -  Grignard-mediated rearrangement of trifluoroacetyl from dihydroisoquinoline enamides to afford tertiary trifluoromethylcarbinols[ ORGANIC & BIOMOLECULAR CHEMISTRY,2018-02-28]

Patent

-  피페리딘-3,5-디카복시아마이드 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물[2015-12-08] -  4-(1-퍼롤-3,4-디카르복시아미드)피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물[2016-06-21] -  4-(2-아미노-테트라하이드로나프탈렌닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물[2016-08-29] -  피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는항암용약학적조성물[2016-09-05] -  피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물[2017-04-28] -  N2-(2-메톡시페닐)피리미딘 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물[2017-08-22] -  화합물 및 염증성 질환 치료용 약학적 조성물[2015-01-02] -  ALK 단백질의 분해를 유도하는 약학적 조성물 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성[2018-01-29] -  암 예방 또는 치료용 약학적 조성물 및 이의 용도[2018-01-29] -  암 예방 또는 치료용 약학적 조성물 및 이의 용도[2018-01-30] -  피리미딘?2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 [2018-04-03]