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김인규 교수

Kim In Gyu

INFO

  • 소속캠퍼스한국원자력연구원
  • 전공 방사선동위원소 응용 및 생명공학
  • 직급전공책임교수
  • 연락처042-868-8030
  • 출신전공생리생화학
  • 학위박사
  • 최종출신대학성균관대학교 자연과학캠퍼스
  • 이메일

연구분야

방사선생물학,방사선종양생물학,세포생물학,생리학, 미생물유전학

radiation biology, radiation oncology, cell and molecular biology, physiology. microbial genetics

대표연구실적

-  Fibulin-3 inhibits Epithelial to Mesenchymal Transition and Self renewal of ALDH+ Lung cancer stem cells via the IGF1Rβ/PI3K/AKT/GSK3β pathway, Oncogene, 2013 (in press) -  2. SM22α inhibits cell proliferation and protects against anticancer drug and ionizing radiation in HepG2 cells: involvement of metallothioneins, FEBS letters Vol. 583, no.20, pp. 3356-3362, 2009.10 -  5. Kim TR, Lee HM, Lee SY, Kim EJ, Kim KC, Paik SG, Cho EW, Kim IG. SM22α-induced activation of p16INK4a/retinoblastoma pathway promotes cellular senescence caused by a subclinical dose of γ-radiation and doxorubicin in HepG2 cells. Biochem Biophys Res Commun Vol. 400, 100-5, 2010

논문(최근 5년)

-  Analysis of surface contributions to external doses in a radioactively contaminated urban environment designed by the EMRAS-2 Urban Areas Working Group[ ANNALS OF NUCLEAR ENERGY,2013-07-01] -  Assessment in marine enviroment for a hypothetic nuclear accident based on the database of tidal harmonic constants[Marine Pollution Bulletin ,2014-10-15] -  Disturbance of DKK1 level is partly involved in survival of lung cancer cells via regulation of ROMO1 and γ-radiation sensitivity[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013-11-20] -  Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH+ lung cancer stem cells through IGF1R signaling[Oncogene,2013-09-09] -  Genistein decreases cellular redox potential, partially suppresses cell growth in HL?60 leukemia cells and sensitizes cells to γ?radiation?induced cell death[MOLECULAR MEDICINE REPORTS,2014-05-28] -  Identification of a mimotope for circulation anti-cytokeratin 8/18 antibody and its usage for the diagnosis of breast cancer[international journal of oncology,2013-01-01] -  Marine dispersion assessment of 137Cs released from the Fukushima nuclear accident[Marine Pollution Bulletin ,2013-07-15] -  Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilzation[Cancer letter,2014-11-01] -  Soil-to-soybean transfer of (99)TC and its underground distribution in differently contaminated upland soils[Journal of Environmental Radioactivity ,2014-02-01] -  TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1[Oncotarget,2014-09-28] -  Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases γ-radiation-induced sensitivity in some pancreatic cancer cell lines.[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014-11-21] -  Tumor-associated mesenchymal stem0like cells provide extracellular signaling cue for invasiveness of glioblastoma cells [ ONCOTARGET,2017-01-03] -  Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer [ ONCOTARGET,2016-08-16] -  PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling.[ ONCOTARGET,2016-01-26] -  Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer.[ CANCER SCIENCE,2015-06-10] -  PKCδ maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback.[ ONCOGENE,2015-11-12] -  Radiation promotes malignant phenotypes through SRC in breast cancer cells.[ CANCER SCIENCE,2015-01-01] -  Cesium Toxicity Alters MicroRNA Processing and AGO1 Expressions in Arabidopsis thaliana[ PLOS ONE,2015-05-06] -  Protective Effect of an Isoflavone, Tectorigenin, Against Oxidative Stress-induced Cell Death via Catalase Activation.[ EUROPEAN JOURNAL OF CANCER PREVENTION,2016-12-02] -  Hyperoside Induces Endogenous Antioxidant System to Alleviate Oxidative Stress.[ EUROPEAN JOURNAL OF CANCER PREVENTION,2016-03-21] -  Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by[Biomolecules and Therapeutics,2016-05-01] -  Activation of KRAS promotes the mesenchymal features of basal-type breast cancer.[ EXPERIMENTAL AND MOLECULAR MEDICINE,2015-01-30] -  Osteopontin production by TM4SF4 signaling drives a positive[ ONCOTARGET,2017-09-18] -  Baicalein Protects Human Skin Cells against Ultraviolet B-Induced[Biomolecules and Therapeutics,2016-11-01] -  APBB1 reinforces cancer stem cell and epithelial-to-mesenchymal[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-11-09]

특허(최근 5년)

-  피불린-3 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 함유하는 비소세포성 폐암 예방 및 치료용 조성물[2012-12-17] -  TSPYL5 유전자 발현을 억제하여 암세포의 화합물 또는 방사선에 대한 민감도를 증진 방법[2013-01-01] -  DKK3 발현 또는 활성 억제제를 함유하는 암 예방 및 치료용 조성물[2013-05-22] -  비소세포성 폐암에서 TM4SF4의 발현 또는 활성의 조절을 통한 방사선저항성 및 암세포의 성장, 전이 및 침윤능력을 저하시키는 방법[2013-04-03] -  에탄올 생산용 재조합 균주를 이용한 알코올 생산방법[2014-05-14] -  피불린-3 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 함유하는 비소세포성 폐암 예방 및 치료용 조성물[2016-06-27] -  피불린-3 단백질을 유효성분으로 함유하는 암 줄기세포 성장억제용 약학적 조성물[2014-09-04] -  c피불린-3 단백질을 유효성분으로 함유하는 암 줄기세포 성장 억제용 약학적 조성물[2015-03-27] -  염생식물을 이용한 방사능 오염 토양 정화방법[2015-11-30] -  비소세포성 폐암에서 TM4SF4의 발현 또는 활성의 조절을 통한 방사선저항성 및 암세포의 성장, 전이 및 침윤능력을 저하시키는 방법[2015-07-07] -  비소세포성 폐암에서 TM4SF4의 발현 또는 활성의 조절을 통한 방사선저항성 및 암세포의 성장, 전이 및 침윤능력을 저하시키는 방법[2016-02-19] -  피불린-4 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 함유하는 폐암 예방 및 치료용 약학적 조성물[2016-06-27] -  FBLN-3 단백질을 유효성분으로 함유하는 췌장암 예방 및 치료용 약학적 조성물[2017-06-05] -  피불린-3 단백질을 유효성분으로 함유하는 암 줄기세포 성장억제용 약학적 조성물[2014-06-18]