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박상현 교수

Park Sang Hyun

INFO

  • 소속캠퍼스한국원자력연구원
  • 전공 방사선동위원소 응용 및 생명공학
  • 연락처063-570-3370
  • 출신전공화학
  • 학위박사
  • 최종출신대학Stevens Institute of Technology
  • 이메일

연구분야

신약 개발

Drug discovery and development

대표연구실적

-  K. C. Ko, M. H. Choi, J. K. Rho and S. H. Park, "A facile method for detecting calcium/calmodulin-dependent protein kinase using radio phosphorylation of a GBP-fused enzyme substrate in a lab-on-a-chip", Sensor. Actuat. B-Chem., Vol. 178, pp. 432-442, Mar., 2013. -  K. Pradeep, K. C. Ko, M. H. Choi, J. A. Kang, Y. J. Chung and S. H. Park, "Protective effect of hesperidin, a flavanoglycone, against γ-radiation-induced tissue damage in Sprague-Dawley rats", J. Med. Food, Vol. 15, No. 5, pp. 419-427, May, 2012. -  J. K. Rho, J. A. Kang, M. H. Choi, K. C. Ko and S. H. Park, "Enhanced kinase sensing by radio-phosphorylation and oriented immobilization of a GBP-linked kinase substrate on a gold surface", Sensor. Actuat. B-Chem., Vol. 160, pp. 632-636, Aug., 2011.

논문(최근 5년)

-  A facile method for detecting calcium/calmodulin-dependent protein kinase using radio phosphorylation of a GBP-fused enzyme substrate in a lab-on-a-chip[Sensors and actuators. B, Chemical,2013-03-01] -  In Vivo Molecular Imaging of [125I]-Labeled 3-Iodothyronamine: A Hibernation-Inducing Agent[Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry, and medicine,2013-01-31] -  Anti-inflammatory action of γ-irradiated genistein in murine peritoneal macrophage[Radiation Physics and Chemistry,2014-06-12] -  Antioxidative activities of Ginkgo biloba extract in oil/water emulsion system prepared from an enzymatically modified lipid containing[Journal of Food Science,2013-01-15] -  Biodistribution of 99mTc tricarbonyl glycine oligomers[Toxicology Research,2012-12-03] -  Effect of ionizing irradiation on in vitro cytotoxic and nitric oxide producing abilities of mistletoe (Viscum Album) extract[Italian Journal of Food Science,2012-12-03] -  Emulsifying properties of lecithin containing different fatty acids obtained by immobilized lecitase ultra-catalyzed reaction[Journal of the American Oil Chemistry Society,2013-12-17] -  Hesperidin and Curdlan treatment ameliorates γ-radiation induced cellular damage and oxidative stress in the liver of Sprague-Dawley rats[Research Journal of Pharmaceutical, Biological and chemical Sciences,2014-07-01] -  Immune-enhancing activity of silk peptide in a gamma ?irradiated mouse model[Italian Journal of Food Science,2012-12-03] -  In Vivo molecular imaging of [125I]-labeled 3-iodothyronamine: A Hibernation-inducing agent[Applied Radiation and Isotopes,2012-12-13] -  Preparation of recombined milk using modified butterfats containing α-linolenic acid[Journal of Food Science,2013-01-15] -  Procyanidin C1 causes vasorelaxation through activation of the endothelial NO/cGMP pathway in thoracic aortic rings[Journal of Medicinal Food,2014-03-23] -  Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages[Biochemical and Biophysical Rsearch Communications,2013-07-16] -  Radoprotective effects of silk peptide on Raw264.7 macrophage cells[Italian Journal of Food Science,2012-12-03] -  The procyanidin trimer C1 induces macrophage activation via NF-kB and MAPK pathways, leading to Th1 polarization in murine splenocytes[European Journal of Pharmacology,2013-06-13] -  The procyanidin trimer C1 inhibits LPS-induced MAPK and NF-kB signaling through TLR4 in macrophages[International Immunopharmacology,2012-12-20] -  Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in lipopolysaccharide-stimulated RAW264.7 macrophages[Bioscience, Biotechnology and Biochemistry,2016-04-12] -  Gold-nanoparticle-immobilized desalting columns for highly efficient and specific removal of radioactive iodine in aqueous media[ ACS APPLIED MATERIALS & INTERFACES,2016-10-19] -  Highly efficient method for 125I-radiolabeling of biomolecules using inverse-electron-demand diels-Alder reaction[ BIOORGANIC & MEDICINAL CHEMISTRY,2016-04-19] -  Critical analysis of radioiodination techniques for micro and macro organic molecules[ JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2016-01-13] -  Synthesis and evaluation of an 125I-labeled azide prosthetic group for efficient and bioorthogonal radiolabeling of cyclooctyne-group containing molecules using copper-free click reaction[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-02-01] -  Radiosynthesis and in vivo evaluation of [125I]2-(4-iodophenethyl)-2-methylmalonic acid as a potential radiotracer for detection of apoptosis[ JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2016-01-01] -  Gamma-irradiated β-glucan induces the immunomodulation and anticancer activity through MAPK and NF-κB pathways[ JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,2015-05-21] -  Cobalt (II) Complexes Containing N’-Substituted N,N’,N-bis((1H-pyrazol-1-yl)methyl)amine Ligands: The Formation of Four-Coordinate or Five-Coordinate Complexes as a Function of the N’-Substitution group in N,N’,N-bis((1H-pyrazol-1-yl)methyl)amine[ INORGANICA CHIMICA ACTA,2015-09-25] -  β-(1, 3)-glucan isolated from Agrobacterium species induces maturation of bone marrow-derived dendritic cells and drives Th1 immune responses[ FOOD SCIENCE AND BIOTECHNOLOGY,2015-08-31] -  Efficient method for iodine radioisotope labeling of cycloocyne-containing molecules using train-promoted copper-free click reaction[ BIOORGANIC & MEDICINAL CHEMISTRY,2015-04-23] -  Radiosynthesis of 123I-labeled hesperetin for biodistribution of orally administered hesperetin[ JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2015-03-28] -  Simple and efficient radiolabeling of hyaluronic acid and its in vivo evaluation via oral administration[ JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2015-02-28] -  Cadmium(II) complexes containing N'-substituted N,N-di(2-picolyl)amine: The formation of monomeric versus dimeric complexes is affected by the N'-substitution group on the amine moiety[ JOURNAL OF ORGANOMETALLIC CHEMISTRY,2015-02-19] -  Palladium(II) Complexes with N,N’-Bidentate N-Methyl-N-(pyridin-2-ylmethyl)aniline and its Derivatives: Synthesis, Characterization, and Methyl Methacrylate Polymerization[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2015-01-23] -  Evaluation of cholesterol absorption inhibition of anti-NPC1L1 IgY by [3H]-labeled cholesterol in Sprague-Dawley rats[ JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2015-02-15] -  Effects of irradation temperature on the sensory quality improvement of Korean traditional marinated raw crab Portunus trituberculatus in soybean sauce[Fisheries and Aquatic Science,2015-04-01] -  Efficient radiolabeling of rutin with 125I and biodistribution study of radiolabeled rutin[ JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2015-09-04] -  Radiosynthesis and preliminary biological evaluation of 99mTc-labeled 2-methyl-2pentylmalonic acid as an apoptosis imaging agent[ JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2017-05-16] -  Gamaa-irradiated resveratrol negatively regulates LPS-induced MAPK and NF-kB signaling through TLR4 in macrophages[ INTERNATIONAL IMMUNOPHARMACOLOGY,2015-02-18] -  Radioprotective effect of quercetin post-treatment against gamma-irradiation-induced hematocellular and hematopoietic system damage in mice [Journal of the Korean Society of Food Science and Nutrition,2015-07-01] -  Radioprotective effect of post-treatment with hesperetin against gamma-irradiation-induced tissue damage and oxidative stress in BALB/c mice [Journal of the Korean Society of Food Science and Nutrition,2015-06-01] -  Introduction of apoptosis by gamma-irradiated apigenin in H1975 human non-small lung cells[Journal of the Korean Society of Food Science and Nutrition,2015-05-01] -  Radioprotective effect of post-treatment with rutin on gamma-irradiation-induced cellular damage in mice [Korean Journal of Food Science and Technology,2015-03-01] -  Effects of wearing bio-active material coated fabric against gamma-irradiation-induced cellular damage in sprague-dawley rats[방사선방어학회지,2016-03-01] -  Eclipta prostrata Improves DSS-Induced Colitis through Regulation of Inflammatory Response in Intestinal Epithelial Cells[ AMERICAN JOURNAL OF CHINESE MEDICINE,2017-06-29] -  Arctigenin Inhibits Lung Metastasis of Colorectal Cancer by Regulating Cell Viability and Metastatic Phenotypes [ MOLECULES,2016-08-27] -  Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages [ AMERICAN JOURNAL OF CHINESE MEDICINE,2015-06-29] -  Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice[Journal of Evidence-Based Complementary and Alternative Medicine,2013-12-31]

특허(최근 5년)

-  방사선 조사를 이용하여 저장 안정성이 개선된 알로에 추출물을유효성분으로 함유하는 조성물 및 이의제조방법[2014-08-19] -  Conductive nanocomolex and method of manufacturing the same[2013-12-24] -  전도성 나노복합체 및 이의 제조방법[2014-07-18] -  테크네튬-99엠이 표지된 금 나노입자-금결합 펩타이드 복합체 제조 방법, 그 방법에 의해 제조된 복합체 및 이의 용도[2014-04-16] -  헤스페리딘을 유효성분으로 함유하는 세포보호용 조성물[2013-08-27] -  누에 체액을 유효성분으로 함유하는 방사선 조사에 의한 조직 손상 예방 및 치료용 약학적 조성물 [2015-07-09] -  아피제닌에 방사선을 조사하여 항암 활성을 향상시키는 방법 및 아피제닌의 방사선 조사 산물을 유효 성분으로 포함하는 암 예방 및 치료용 약학 조성물[2016-11-29] -  레즈베라트롤에 방사선을 조사하여 항염증 활성을 향상시키는 방법 및 레즈베라트롤의 방사선 조사 산물을 유효 성분으로 포함하는 염증 개선용 조성물[2017-07-03] -  방사성 요오드 표지 아자이드 추적체, 이의 제조방법 및 이를 유효성분으로 포함하는 방사성 요오드 표지 또는 의료 진단용 조성물[2017-05-01] -  방사성 요오드 표지 아자이드 화합물 및 이를 유효성분으로 포함하는 방사성 요오드 표지 조성물[2017-07-03] -  pharmaceutical composition comprising silkworm as an active ingredient for prevention and treatment of tissue injury by radiation[2017-04-04]