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한영훈 교수

Young-Hoon Han

INFO

  • 소속캠퍼스한국원자력의학원
  • 전공 방사선종양의과학
  • 연락처02-970-1316
  • 출신전공미생물학과
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일

연구분야

방사선 반응 microRNA 활용 연구

Studies on radiation response-reguating microRNA

대표연구실적

-  An HJ et al./Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2/BBA-Mol Basis Dis1862: 1926-1937 -  Kwak SY et al./miR-5003-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization and direct targeting of E-cadherin/J Mol cell Biol 8: 372-383 -  Yoo JO et al./miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG/BBA-Mol Cell Res 1863: 1601-1611

논문(최근 5년)

-  Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B RhoGAP[BBA-Mol. Cell. Res.,2014-03-01] -  bb-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species[Oncology Lett.,2014-06-01] -  3-Hydroxy-3′4′-dimethoxyflavone suppresses Bcl-w-induced invasive potentials and stemness in glioblastoma multiforme[Biochem. Biophys. Res. Comm.,2014-07-18] -  ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer[ ONCOTARGET,2015-02-20] -  Ionizing radiation-inducible miR-30e promotes glioma cell invasion through EGFR stabilization by directly targeting CBL-B[ FEBS JOURNAL,2015-04-15] -  miR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2[ ONCOTARGET,2015-07-30] -  Identification of novel therapeutic targets in the secretome of ionizing radiation?induced senescent tumor cells[ ONCOLOGY REPORTS,2016-02-15] -  miR-181b-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization by directly targeting YWHAG[ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2016-07-15] -  miR-5003-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization and direct targeting of E-cadherin[ JOURNAL OF MOLECULAR CELL BIOLOGY,2016-06-15] -  Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2[ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2016-10-15] -  IL-4, a direct target of miR-340/429, is involved in radiation-induced aggressive tumor behavior in human carcinoma cells[ ONCOTARGET,2016-12-20] -  miR-550a-3-5p acts as a tumor suppressor and reverses BRAF inhibitor resistance through the direct targeting of YAP[CELL DEATH & DISEASE,2018-05-29]

특허(최근 5년)

-  miR-5582-5p를 포함하는 항암제[2017-05-12]

연구과제 수행 실적

HIF1a 타겟팅 miR-5586-5p에 의한 유방암 전이 조절기전 규명 및 활용 연구 간엽성 뇌암줄기세포 타겟팅을 통한 악성 뇌암의 혈뇌장벽 극복 방사선 신치료기술 개발 방사선반응제어 실용화기술개발 방사선반응제어실용화기술개발사업 HIF1a 타겟팅 miR-5586-5p에 의한 유방암 전이 조절 기전 규명 및 활용 연구