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이민영 교수

Minyoung Lee

INFO

  • 소속캠퍼스한국원자력의학원
  • 전공 방사선종양의과학
  • 연락처02-970-1637
  • 출신전공의학
  • 학위박사
  • 최종출신대학경희대학교
  • 이메일

연구분야

대장암의 전이 및 치료 저항성 획득 과정에서 암대사와 당쇄화의 관계 연구

The reciprocal regulation of metabolism and glycosylation in the metastasis and therapeutic resistance of colorectal cancer

대표연구실적

-  Yu Ri Jung, Eun Ju Kim, Hyeong Jwa Choi, Jung-Jin Park, Hak-Su Kim, Yoon-Jin Lee, Myung-Jin Park, Minyoung Lee/Aspirin targets SIRT1 and AMPK io induce senescence of colorectal carcinoma cells/Molecular Pharmacology/2015.7.28 -  Jung-Jin Park, Jae Youn Yi, Yueng Bae Jin, Yoon-Jin Lee, Jae-Seon Lee, Yun-Sil Lee, Young-Gyu Ko, Minyoung Lee/Sialylation of EGFR regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells/Biochemical pharmacology/2012.1.13 -  Minyoung Lee, Hae-June Lee, Sangwoo Bae, Yun-Sil Lee/Protein sialylation by sialyltransferase involves radiation resistance/Molecular cancer research/2008.4.4

논문(최근 5년)

-  Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation[Oncology reports,2014-10-06] -  Involvement of corin downregulation in ionizing radiation-induced senescence of myocardial cells[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2015-03-01] -  Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II alpha[Cancer Biology and therapy,2015-04-13] -  Radiation promotes malignant phenotypes through SRC in breast cancer cells[Cancer Science,2015-01-01] -  SIGN-R1 and complement factors are involved in the systemic clearance of radiation-induced apoptotic cells in whole-body irradiated mice[Biochemical and Biophysical Research Communications,2015-06-12] -  Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells[Molecular Pharmacology,2015-10-01] -  Silencing of ST6Gal I enhances coloretal cancer metastasis by down-regulating KAI1 via exosome-mediated exportations and thereby rescues integrin signaling [ CARCINOGENESIS,2016-08-24] -  Abberant DNA methylation-induced gene inactivation is associated with the diagnosis and/ or therapy of T-cell leukemias [ LEUKEMIA RESEARCH,2016-05-27] -  Identification of novel therapeutic targets in the secretome of ionizing radiation-induced senescenct tumor cells[ ONCOLOGY REPORTS,2016-01-04] -  Humanizing NOD/SCID/IL-2R?null (NSG) mice using busulfan and retro-orbital injection of umbilical cord blood-derived CD34+ cells[Blood Research,2016-03-08] -  Metformin displays in vitro and in vivo anti tumor effect against osteosarcoma [Korean Journal of Pediatrics,2016-08-08] -  A novel topoisomerase 2a inhibitor, cryptotanshinone, suppresses the growth of PC3 cells without apparent cytotoxicity [ TOXICOLOGY AND APPLIED PHARMACOLOGY,2017-07-24] -  Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase [ CELL DEATH & DISEASE,2017-03-22] -  FYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5/NOTCH2 signaling node[ONCOGENE,2018-01-19]

특허(최근 5년)

-  백혈병 진단용 바이오마커 조성물 및 이를 이용한 진단방법[2017-12-27] -  RKIP를 포함하는 방사선 피폭 진단용 바이오마커 조성물 및 이를 이용한 진단방법[2018-03-05] -  카베올린―1을 포함하는 방사선 피폭 진단용 바이오마커 조성물 및 이를 이용한 진단방법[2018-03-05]

연구과제 수행 실적

실험동물기반 방사선의학연구