본문 바로가기 대메뉴 바로가기
Hae-June Lee(Professor)

INFO

  • AffiliationKorea Institute of Radiological & Medical Sciences
  • Majors Radiological & Medico-Oncological Sciences
  • Contact Information02-970-1638
  • Major수의학과(수의해부학)
  • DegreePh.D.
  • Highest Level of Education전남대학교
  • E-Mail

Field of Research

Radiation Biology

Research Results

-  Lee HJ, Yoon C, Schmidt B, Park DJ, Zhang AY, Erkizan HV, Toretsky JA, Kirsch DG, Yoon SS/Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage/Mol Cancer Ther/ 2013 Nov -  Lee HJ, Kwon HC, Chung HY, Lee YJ, Lee YS//Recovery from radiation-induced bone marrow damage by HSP25 through Tie2 signaling/Int J Radiat Oncol Biol Phys/2012 Sep 1 -  Jeong YJ, Son Y, Han NK, Choi HD, Pack JK, Kim N, Lee YS, Lee HJ/Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice/Int J Mol Sci/2018 Jul 19

Treatise

-  Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss-Side Effect.[JOURNAL OF CLINICAL MEDICINE,2019-02-11] -  Oridonin Enhances Radiation-Induced Cell Death by Promoting DNA Damage in Non-Small Cell Lung Cancer Cells[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018-08-13] -  Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018-07-19] -  Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization.[Nature Communications,2018-11-30] -  Early Detection of Aβ Deposition in the 5xFAD Mouse by Amyloid PET.[CONTRAST MEDIA & MOLECULAR IMAGING,2018-02-28] -  Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation.[Oncogene,2018-03-21] -  Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer.[Neuropharmacology,2018-03-21] -  FYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5/NOTCH2 signaling node.[Oncogene,2018-01-19] -  Long-term RF exposure on behavior and cerebral glucose metabolism in 5xFAD mice.[Neuroscience Letters,2018-02-14] -  Silibinin attenuates radiation-induced intestinal fibrosis and reverses epithelial-to-mesenchymal transition.[Oncotarget,2017-09-02] -  Geranylgeranylacetone Ameliorates Intestinal Radiation Toxicity by Preventing Endothelial Cell Dysfunction.[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017-10-07] -  NQO1 inhibits proteasome-mediated degradation of HIF-1α.[Nature Communications,2016-12-14] -  Identification of radiation response genes and proteins from mouse pulmonary tissues after high-dose per fraction irradiation of limited lung volumes.[INTERNATIONAL JOURNAL OF RADIATION BIOLOGY,2017-02-01] -  Geranylgeranylacetone alleviates radiation-induced lung injury by inhibiting epithelial-to-mesenchymal transition signaling[MOLECULAR MEDICINE REPORTS,2016-06-01] -  Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer.[Oncotarget,2016-08-16] -  1950 Hz radiofrequency electromagnetic fields do not aggravate memory deficits in 5xFAD mice.[Bioelectromagnetics,2016-09-30] -  Silicon Dioxide Nanoparticles Enhance Endotoxin-Induced Lung Injury in Mice[Molecules,2018-09-03] -  Effects of NOX1 on fibroblastic changes of endothelial cells in radiation-induced pulmonary fibrosis[Molecular Medicine Reports,2016-04-05] -  HSPB1 Inhibits the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis.[CANCER RESEARCH,2016-03-01] -  PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling[Oncotarget,2016-01-26] -  Continuous Exposure to Low-Dose-Rate Gamma Irradiation Reduces Airway Inflammation in Ovalbumin-Induced Asthma.[PLoS ONE,2015-11-20] -  Heat shock factor 1, an inhibitor of non-homologous end joining repair.[Oncotarget,2015-10-06] -  The ameliorative effect of silibinin against radiation-induced lung injury: protection of normal tissue without decreasing therapeutic efficacy in lung cancer.[BMC Pulmonary Medicine,2015-07-05] -  Coniferyl aldehyde attenuates radiation enteropathy by inhibiting cell death and promoting endothelial cell function.[PLoS ONE,2015-06-01] -  1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer's Disease Mice[CURRENT ALZHEIMER RESEARCH,2015-06-30] -  Pirfenidone enhances the efficacy of combined radiation and sunitinib therapy.[Biochemical and Biophysical Research Communications,2015-06-26] -  Coniferyl aldehyde reduces radiation damage through increased protein stability of heat shock transcriptional factor 1 by phosphorylation.[INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2015-03-15] -  Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature.[INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2015-03-01] -  Chemical chaperones reduce ionizing radiation-induced endoplasmic reticulum stress and cell death in IEC-6 cells.[Biochemical and Biophysical Research Communications,2014-07-25] -  CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance.[CLINICAL CANCER RESEARCH,2014-08-01] -  A Hypoxia-Induced Vascular Endothelial-to-Mesenchymal Transition in Development of Radiation-Induced Pulmonary Fibrosis.[Clinical Cancer Research,2015-08-15] -  Evaluation of premature senescence and senescence biomarkers in carcinoma cells and xenograft mice exposed to single or fractionated irradiation.[Oncology Reports,2014-05-01] -  Radiation promotes invasiveness of non-small-cell lung cancer cells through granulocyte-colony-stimulating factor[Oncogenesis,2015-10-16] -  Hypoxia-activated chemotherapeutic TH-302 enhances the effects of VEGF-A inhibition and radiation on sarcomas[British Journal of Cancer,2015-06-30] -  The Effect of Sub-Chronic Whole-Body Exposure to a 1,950 MHz Electromagnetic Field on the Hippocampus in the Mouse Brain[Journal of Electromagnetic Engineering and Science,2015-07-31] -  A Preclinical Rodent Model of Acute Radiation-Induced Lung Injury after Ablative Focal Irradiation Reflecting Clinical Stereotactic Body Radiotherapy[Radiation Research,2014-06-30] -  Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules.[Oncotarget,2016-07-16]