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kim, jae-sung(Professor)

INFO

  • AffiliationKorea Institute of Radiological & Medical Sciences
  • Majors Radiological & Medico-Oncological Sciences
  • Contact Information02-970-1669
  • Major생명과학과
  • DegreePh.D.
  • Highest Level of Education광주과학기술원
  • E-Mail

Field of Research

Radiation therapy, Radiation resistance, Tumor resistance, Cell cycle, Tumor metabolism

Research Results

-  JS Kim, EJ Kim, JS Oh, IC Park, SG Hwang. CIP2A modulates cell cycle progression in human cancer cells by regulating Plk1 stability and activity. Cancer Res. 2013 Nov 15;73(22):6667-78. (corresponding) -  Choe MH, Min JW, Jeon HB, Cho DH, Oh JS, Lee HG, Hwang SG, An S, Han YH, Kim JS. ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer. Oncotarget. 2015 Feb 20;6(5):2654-66. (corresponding) -  Kim MO, Choe MH, Yoon YN, Ahn J, Yoo M, Jung KY, An S, Hwang SG, Oh JS, Kim JS.Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells. Biochem Pharmacol. 2017 Aug 13. (corresponding)

Treatise

-  Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo[Biochem Biophys Res Commun,2014-03-20] -  Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II alpha[ CANCER BIOLOGY & THERAPY,2015-04-03] -  ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer[ ONCOTARGET,2015-02-20] -  Dynamics of histone H3 phosphorylation at threonine 3 during meiotic maturation in mouse oocytes[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-03-06] -  Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells[ PLOS ONE,2015-02-11] -  Autocrine Action of Thrombospondin-2 Determines the Chondrogenic Differentiation Potential and Suppresses Hypertrophic Maturation of Human Umbilical Cord Blood-derived Mesenchymal Stem Cells. Stem Cells[ STEM CELLS,2015-11-01] -  Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis[ SCIENTIFIC REPORTS,2015-10-21] -  Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-01-01] -  Proton Irradiation Sensitizes Radioresistant Non-small Cell Lung Cancer Cells by Modulating Epidermal Growth Factor Receptor-mediated DNA Repair[ ANTICANCER RESEARCH,2016-01-01] -  STAT3-survivin signaling mediates a poor response to radiotherapy in HER2-positive breast cancers[ ONCOTARGET,2016-02-09] -  TCTP regulates spindle microtubule dynamics by stabilizing polar microtubules during mouse oocyte meiosis[ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2016-04-01] -  Beclin-1 knockdown shows abscission failure but not autophagy defect during oocyte meiotic maturation[ CELL CYCLE,2016-06-17] -  Radiotherapy diagnostic biomarkers in radioresistant human H460 lung cancer stem-like cells[ CANCER BIOLOGY & THERAPY,2016-02-01] -  Prognostic Value of Anti-Mullerian Hormone and Inhibin B in Patients with Premenopausal Hormone Receptor-positive Breast Cancer[ ANTICANCER RESEARCH,2016-03-01] -  Eccentric localization of catalase to protect chromosomes from oxidative damages during meiotic maturation in mouse oocytes[ HISTOCHEMISTRY AND CELL BIOLOGY,2016-09-01] -  Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2[ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE,2016-10-01] -  Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin[ ARCHIVES OF PHARMACAL RESEARCH,2016-08-01] -  TCTP regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality[ BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2017-07-01] -  Peroxiredoxins are required for spindle assembly, chromosome organization, and polarization in mouse oocytes[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-07-22] -  Antihelminthic drug niclosamide inhibits CIP2A and reactivates tumor suppressor protein phosphatase 2A in non-small cell lung cancer cells[ BIOCHEMICAL PHARMACOLOGY,2017-08-01] -  CIP2A acts as a scaffold for CEP192-mediated MTOC assembly by recruiting Plk1 and Aurora A during meiotic maturation[ DEVELOPMENT,2017-09-01] -  The Small Molecule AU14022 Promotes Colorectal Cancer Cell Death via p53-mediated G2/M-phase Arrest and Mitochondria-mediated Apoptosis[ JOURNAL OF CELLULAR PHYSIOLOGY,2017-10-01]

Patent

-  HNRNPUL1을 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도 [2014-03-13] -  PSAP를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도[2014-12-01] -  CDK11A를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도[2014-08-13] -  MRFAP1을 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도[2014-08-13] -  WDFY3을 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도[2014-11-25] -  CDC27을 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도 [2014-07-31] -  후두암 또는 후두암의 방사선 저항성의 진단을 위한 조성물 및 진단방법[2016-08-02] -  방사선 내성 암 치료용 약학 조성물[2017-08-23] -  IN VITRO METHOD OF INHIBITING THE GROWTH OF RADIORESISTANT LARYNEGEAL CANCER CELLS[2017-03-07] -  miR-5582-5P를 포함하는 항암제[2017-05-12]