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JONG KUK, PARK(Professor)

INFO

  • AffiliationKorea Institute of Radiological & Medical Sciences
  • Majors Radiological & Medico-Oncological Sciences
  • Contact Information02-970-1321
  • Major분자세포생물학
  • DegreePh.D.
  • Highest Level of Education서강대학교
  • E-Mail

Field of Research

Investigation of Effectiveness Improvement of Radiatio-therapy against Cancer

Research Results

-  박종국 외 6인/Luteolin acts as a radiosensitizer in non small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade/Int J Oncol/2015 -  박종국 외 6인/Podophyllotoxin acetate enhances γ-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway/Biomedicine & Pharmacotherapy/2015 -  박종국외 7인/ICAM-3 endows anticancer drug resistance against microtubule-damaging agents via activation of the ICAM-3-AKT/ERK-CREB-2 pathway and blockage of apoptosis/Biochem Biophys Res Commun/2013

Treatise

-  Luteolin acts as a radiosensitizer in non small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade[Int J Oncol,2014-12-09] -  Podophyllotoxin acetate enhances γ-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway[ BIOMEDICINE & PHARMACOTHERAPY,2014-12-31] -  Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion[EMBO Rep,2014-08-20] -  Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins[Oncotarget,2014-08-06] -  Knockdown of hepatoma-derived growth factor-related protein-3 induces apoptosis of H1299 cells via ROS-dependent and p53-independent NF-κB activation[Biochem Biophys Res Commun,2014-05-22] -  Src and epidermal growth factor receptor mediate the pro-invasive activity of Bcl-w[ TUMOR BIOLOGY,2016-06-01] -  Gamma-Ionizing radiation-induced activation of the EGFR-p38/ERK-STAT3/CREB-1-EMT pathway promotes the migration /invasion of non-small cell lung cancer cells and is inhibited by podpphyllotoxin acetate[ TUMOR BIOLOGY,2015-12-15] -  Podophyllotoxin acetate triggers anticancer effects against non-small cell lung cancer cells by promoting cell death via cell cycle arrest, ER stress and autophagy[ INTERNATIONAL JOURNAL OF ONCOLOGY,2015-10-01] -  Chemosensitizing effect of podophyllotoxin acetate on topoisomerase inhibitors leads to synergistic enhancement of lung cancer cell apoptosis [ INTERNATIONAL JOURNAL OF ONCOLOGY,2016-06-01] -  Involvement of SULF2 in gamma-irradiation-induced invasion and resistance of cancer cells by inducing IL-6 expression[ ONCOTARGET,2016-02-17] -  The p53/p21 complex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins[ CANCER RESEARCH,2017-04-04]

Patent

-  CDK11A를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조 성물 및 이의 용도[2014-08-13] -  MRFAP1 을 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조 성물 및 이의 용도[2014-08-13] -  HNRNPUL1 을 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단 용 조성물 및 이의 용도[2014-08-13] -  CDC27 을 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성 물 및 이의 용도[2014-08-13] -  PSAP를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도[2014-12-01] -  WDFY3를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도[2014-11-25] -  포도필로톡신 아세테이트를 유효성분으로 포함하는 방사선 치료 증진제[2015-12-15] -  항암제 내성 예측용 바이오마커로서의 ICAM-3 및 이의 용도[2016-11-04] -  Bax/complex-1 복합체를 이용한 암전이 억제제의 스크리닝 방법[2016-03-24] -  p21의 c-말단 영역을 이용한 암전이 억제제의 스크리닝 방법[2016-05-02] -  방사선 내성 암치료용 약학 조성물[2017-08-23]