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Sangyong Lim

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  • 소속캠퍼스한국원자력연구원
  • 전공 방사선 과학기술
  • 직급전공책임교수
  • 연락처063-570-3141
  • 출신전공식품공학
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일

연구분야

방사선 미생물학

Radiation Microbiology

대표연구실적

-  Lim, S, J-H Jung, L Blanchard, and A de Groot/ Conservation and diversity of radiation and oxidative stress resistance mechanisms in Deinococcus species/ FEMS Microbiology Reviews/ In press, 2018 -  Park, S-H, H Singh, D Appukuttan, S Jeong, YJ Choi, J-H Jung, I Narumi, and S Lim/ PprM, a cold-shock domain-containing protein from Deinococcus radiodurans, confers oxidative stress tolerance to Escherichia coli/ Frontiers in Microbiology/Jan. 10, 2017 -  Jung, K-W, D-H Yang. M-K Kim, HS Seo, S. Lim, and Y-S Bahn/ Unraveling fungal radiation resistance regultory network through the genome-wide transcriptome and genetic analyses of Cryptococcus neoformans/ mBio/ Nov. 29, 2016

논문(최근 5년)

-  Spirosoma radiotolerans sp. nov., a gamma-radiation-resistant bacterium isolated from gamma ray-irradiated soil[Current Microbiology,2014-09-01] -  Hymenobacter swuensis sp. nov., a gamma-radiation-resistant bacteria isolated from mountain soil[Current Microbiology,2014-03-01] -  Induction of apoptosis by deinoxanthin in human cancer cells[Anticancer Research,2014-04-01] -  Complete genome sequence of Hymenobacter swuensis, an ionizing-radiation resistant bacterium isolated from mountain soil[Journal of Biotechnology,2014-05-01] -  Molecular cloning and expression of amylosucrase from highly radiation-resistant Deinococcus radiopugnans[Food Science and Biotechnology,2014-06-01] -  Hsp20, a small heat shock protein of Deinococcus radiodurans, confers tolerance to hydrogen peroxide in Escherichia coli[Journal of Microbiology and Biotechnology,2014-08-01] -  Deinococcus radioresistens sp. nov., a UV and gamma radiation-resistant bacterium isloated from mountain soil[Antonie van Leeuwenhoek,2015-02-01] -  Expression and mutational analysis of DinB-like protein DR0053 in Deinococcus radiodurans[PLoS One,2015-02-01] -  Antioxidant activities of fucoidan degraded by gamma irradiation and acidic hydrolysis[Radiation Physics and Chemistry,2015-04-01] -  Temporal regulation of Salmonella pathogenicity island 1 (SPI-1) hilA by Hfq in Salmonella enterica serovar typhimurium[Journal of Korean Society for Applied Biological Chemistry,2015-04-01] -  Deinococcus puniceus sp. nov., a bacterium isolated from soil-irradiated gamma radiation[Current Microbiology,2015-04-01] -  Microalgal lipid production using the hydrolysates of rice straw pretreatd with gamma irradiation and alkali solution[Biotechnolgy for Biofuels,2015-08-01] -  Effect of gamma irradiation on physiological and proteomic changes of Arctic Zygnema sp. (Chlorophyta, Zygnematales)[Phycologia,2015-08-01] -  Deinococcus metallilatus sp. nov. and Deinococcus carri sp. nov., islated from a car air-conditioning system[International Journal of Systematic and Evolutionary Microbiology,2015-09-01] -  Binding of the Streptococcus gordonii surface glycoprotein Hsa to α(2-3) linked sialic acid residues on fibronectin[Journal of Bacteriology and Virology,2014-12-01] -  Roles of outer membrane vesicles (OMVs) in bacterial virulence[Journal of Bacteriology and Virology,2015-03-01] -  Transcriptional profiling of an attenuated Salmonella Typhimurium ptsI mutant strain under low-oxygen conditions using microarray analysis[Journal of Bacteriology and Virology,2015-09-01] -  Melitin, a honeybee venom-derived antimicrobial peptide, may target methicillin-resistant Staphylococcus aureus[MOLECULAR MEDICINE REPORTS,2015-10-01] -  Spirosoma pulverius sp. nov., a bacterium isolated from a dust sample collected at Chungnam province, South Korea [JOURNAL OF MICROBIOLOGY,2015-11-01] -  DNA binding fluorescent proteins for the direct visualization of large DNA molecules[NUCLEIC ACIDS RESEARCH,2015-08-11] -  Inactivation of fungal contaminants on Korean traditional cashbox by gamma irradiation[RADIATION PHYSICS AND CHEMISTRY,2016-02-01] -  Deinococcus actinosclerus sp. nov., a novel bacterium isolated from soil of a rocky hillside[INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY,2016-05-01] -  Single-molecule visualization o ROS-induced DNA damage in large DNA molecules[ANALYST,2016-07-01] -  Flavisolibacter tropicus sp. nov., isolated from tropical soil[INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY,2016-07-01] -  Deinococcus seoulensis sp. nov., a bacterium isolated from sediment at Han River in Seoul, Republic of Korea[JOURNAL OF MICROBIOLOGY,2016-08-01] -  Analysis of alcohol-induced DNA damage in Escherichia coli by visualizing single genomic DNA molecules[ANALYST,2016-10-01] -  Deinococcus persicinus sp. nov., a radiation-resistant bacterium from soil[INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY,2016-10-01] -  Spirosoma fluminis sp. nov., a Gamma-radiation resistant bacterium isolated from sediment of the Han river in South Korea[CURRENT MICROBIOLOGY,2016-11-01] -  Isolation and proteomic analysis of a Chlamydomonas reinhardtii mutant with enhanced lipid production by the gamma irradiation method[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2016-12-01] -  Deinococcus rubellus sp. nov., bacteria isolated from the muscle of antartic fish[JOURNAL OF MICROBIOLOGY,2016-12-01] -  Deinococcus sedimenti sp. nov., isolated from river sediment[JOURNAL OF MICROBIOLOGY,2016-12-01] -  Deinococcus ruber sp. nov., a radiation-resistant bacterium isolated from soil[INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY,2017-01-01] -  Oxidative stress response of Deinococcus geothermalis via a cystine importer[JOURNAL OF MICROBIOLOGY,2017-02-01] -  Dedinococcus rubrus sp. nov., a bacterium isolated from Antartic coastal sea water[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2017-03-01] -  Molecular characterization of pneumococcal surface protein K, a potential pneumococcal vaccine antigern[VIRULENCE,2017-06-01] -  Vaccination with a latch peptide provides serotype-independent protection against group B Streptococcus infection in mice[JOURNAL OF INFECTIOUS DISEASES,2018-01-01] -  Development of a multiplexed opsonophagocytic killing assay (MOPA) for group B Streptococcus[HUMAN VACCINES & IMMUNOTHERAPEUTICS,2018-01-01] -  Status of group B streptococcal vaccine development[Clinical and Experimental Vaccine Research,2018-04-01] -  Deinococcus koreensis sp. nov., a gamma radiation-resistant bacterium isolated from river water[INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY,2018-08-01] -  Roseomonase radiodurans sp. nov., a gamma radiation-resistant bacterium isolated from gamma ray-irradiated soil [INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY,2018-08-01] -  Engineering synthetic multistress tolerance in Escherichia coli by using a deinococcal response regulator, DR1558[APPLIED AND ENVIRONMENTAL MICROBIOLOGY,2016-02-01] -  The three catalases in Deinococcus radiodurans: Only two show catalase activity[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-04-01] -  PprM is necessary for up-regulation of katE1, encoding the majo catalase of Deinococcus radiodurans, under unstressed culture[JOURNAL OF MICROBIOLOGY,2016-06-01] -  Unraveling fungal radiation resistance regulatory networks through the genome-wide transcriptome and genetic analyses of Cryptococcus neoformans[MBIO,2016-11-01] -  PprM, a cold shock domain-containing protein from Deinococcus radiodurans, confers oxidative stress tolerance to Escherichia coli[FRONTIERS IN MICROBIOLOGY,2017-01-01] -  Microbial radiation-resistance mechanisms[JOURNAL OF MICROBIOLOGY,2017-07-01] -  Transcriptional analysis of the iagB within Salmonella pathogenicity island 1 (SPI1)[Journal of Bacteriology and Virology,2016-09-01] -  Deinococus radiodurans 유래 DR1558과 PprM에 의한 Corynebacterium glutamicum의 라이신 생산 향상 연구[Microbiology and Biotechnology Letters,2017-08-01] -  방사선분자변환기술 기반 천연 생물소재 구조변환에 따른 가공적성 및 생리활성 증진 연구[Korean Journal of Food Science and Technology,2018-03-01]

특허(최근 5년)

-  방사선 조사를 이용한 항산화 활성을 갖는 유산균의 배양방법[2014-09-26] -  카로티노이드를 고농도로 생산하는 변이주 아스로박터 M486(Arthrobacter sp. M486) 및 이를 이용한 카로티노이드 생산 방법[2014-10-24] -  방사선 저항성 미생물 유래 DR1558 단백질을 활용한 환경 내성 대장균 균주 제작[2015-09-23] -  방사선 및 알칼리 병용 전처리를 이용한 볏짚 당화 방법 및 이를 이용한 미세조류 지질 생산 방법[2016-12-02] -  데이노코커스 라디오두란스 유래 엑소폴리사카라이드 및 이를 포함하는 조성물[2017-09-04] -  스트랩토코커스 아갈락티아 사균 백신의 제조 방법 및 이로부터 제조된 백신 조성물[2017-07-03] -  스트랩토코커스 뉴모니아 사균 백신의 제종 방법 및 이로부터 제조된 백신 조성물[2017-07-03] -  신규 암 치료용 살모넬라 균주 및 이의 용도[2017-08-25] -  환경 스트레스에 대한 내성을 가지는 재조합 미생물의 개발[2018-01-08] -  유전자 발현 정보 제공 장치[2018-08-27]

연구과제 수행 실적

Cryptococcus 방사선 반응 전사체를 활용한 RAD-NET 개발 및 검증 미생물 방사선 반응 시스템 규명 및 활용 연구 방사선기반 백신 생산기술개발 방사선 저항성 미생물 BANK 구축 및 미생물 재설계 플랫폼 국축 방사선 기반 백신 생산기술 개발