본문 바로가기 대메뉴 바로가기
이종화 교수

JONG-HWA LEE

INFO

  • 소속캠퍼스안전성평가연구소
  • 전공 인체 및 환경 독성학
  • 연락처042-610-8092
  • 출신전공약제과학
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일

연구분야

독성동태, 약물동태, 생체시료분석, 약물대사

Toxico-/Pharmacokinetics, Bioanalysis, Drug metabolism

대표연구실적

-  Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats -  Gender Differences in the Hepatic Elimination and Pharmacokinetics of Lobeglitazone in Rats -  A novel HPLC?MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics

논문(최근 5년)

-  A 14-Day Repeated Dose Toxicity of Epimedii Herba Aqueous Extract Administered by Oral Gavage in F344 Rats[생약학회지,2014-11-18] -  A novel HPLC?MS/MS method for the simultaneous determination of astemizole and its major metabolite in dog or monkey plasma and application to pharmacokinetics[ JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2015-05-21] -  The identification of lobeglitazone metabolites in rat liver microsomes and the kinetics of the in vivo formation of the major metabolite M1 in rats[ JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2015-07-30] -  Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats[ JOURNAL OF PHARMACEUTICAL SCIENCES,2015-02-03] -  Gender Differences in the Hepatic Elimination and Pharmacokinetics of Lobeglitazone in Rats[ BIOPHARMACEUTICS & DRUG DISPOSITION,2015-05-15] -  Development of QTc prolongation model incorporating circadian rhythm using harmonic model[ XENOBIOTICA,2014-12-05] -  Quantification of zabofloxacin in rat plasma using HPLC-UV detector and its application to a Pharmacokinetic study[ JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2014-01-01] -  Evaluation of the Antioxidant Activity and Physiological Functionality of Baegilju[한국미생물·생명공학회지,2013-12-18] -  Development and Evaluation of Gastro Retentive Floating Matrix Tablet Contanining Valsartan Solid Dispersion[KSBB Journal,2016-11-25] -  Effect of Polyethylene Glycol on Physicochemical Property in Dispersing Film Formulation[KSBB Journal,2016-12-28] -  Pharmacokinetics of the phage endolysin-based candidate drug SAL2000 in monkeys and its appropriate intravenous dosing period[Clinical and Experimental Pharmacology and Physiology,2016-06-09] -  Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs[ REGULATORY TOXICOLOGY AND PHARMACOLOGY,2016-09-21] -  Stability Improvement of Esomeprazole Magnesium Dihydrate Enteric-Coated Tablet by Adding Alkalizing Agents[KSBB Journal,2017-06-02] -  Development of a LC?MS/MS method for the determination of CKD-712 in rat plasma: Application to a pharmacokinetic study in rats[ JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2017-07-06] -  Development and validation of a liquid chromatography?tandem mass spectrometry method for the assay of tafamidis in rat plasma: Application to a pharmacokinetic study in rats[ JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017-01-10] -  Feasibility of the functional expression of the human organic anion transporting polypeptide 1B1 (OATP1B1) and its genetic variant 521T/C in the mouse liver[ EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016-09-10] -  Quantification of EC-18, a synthetic monoacetyldiglyceride(1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol), in rat and mouse plasma by liquid-chromatography/tandem mass spectrometry[ JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2017-01-17] -  Specific Inhibition of the Distribution of Lobeglitazone to the Liver by Atorvastatin in Rats: Evidence for a Rat Organic Anion Transporting Polypeptide 1B2?Mediated Interaction in Hepatic Transport [ DRUG METABOLISM AND DISPOSITION,2017-01-05] -  Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC?MS/MS for application to a pharmacokinetic study in rats[ JOURNAL OF SEPARATION SCIENCE,2017-07-19] -  AValidated HPLC?MS/MS Method for the Quantification of Supinoxin in Rat Plasma and Its Application to Pharmacokinetic Study[ ACTA CHROMATOGRAPHICA,2016-09-30] -  Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats[ JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2018-01-03]